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Crystal structure of the RSC4 tandem bromodomain

Analyse Crystal structure of the RSC4 tandem bromodomain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2R0S
Type: protein
Length: 285 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromatin structure-remodeling complex protein RSC4
UniProt: Q02206
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chromatin structure-remodeling complex protein RSC4	protein	285	62% helix, 1% strand	Q02206

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.72	0.83	37	empty
2	273	0.60	0.78	36	empty
3	95	0.50	0.82	16	empty
4	80	0.47	0.81	15	empty

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2R0S · Crystal Structure of the Rsc4 tandem bromodomain · the same entry in another collection · chain A against A, TM-score 1.00
Q02206 · AlphaFold monomer V2.0 prediction for chromatin structure-remodeling complex subunit RSC4… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02206
Elsewhere: RCSB PDB 2R0S · PDBe 2R0S · UniProt Q02206

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