Research workbench
Protease domain of hgfa with inhibitor FAB58
Analyse Protease domain of hgfa with inhibitor FAB58 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R0K
- Type
- protein
- Length
- 666 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor activator; Antibody light chain of FAB58; Antibody heavy chain…
- EC
- 3.4.21.-
- UniProt
- Q04756
- Pockets
- 7 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hepatocyte growth factor activator (EC 3.4.21.-) | protein | 239 | 10% helix, 35% strand | Q04756 |
| L | Antibody light chain of FAB58 | protein | 214 | 6% helix, 48% strand | — |
| H | Antibody heavy chain of FAB58, Fab portion only | protein | 213 | 3% helix, 54% strand | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 493 | 0.59 | 0.74 | 59 | empty |
| 2 | 50 | 0.54 | 0.90 | 18 | empty |
| 3 | 162 | 0.51 | 0.78 | 30 | empty |
| 4 | 204 | 0.50 | 0.76 | 31 | empty |
| 5 | 81 | 0.40 | 0.79 | 20 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1812 Ų buried · 15 hydrogen bonds · protein-protein
- A–H · 804 Ų buried · 9 hydrogen bonds · protein-protein
- A–L · 115 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04756
- Elsewhere: RCSB PDB 2R0K · PDBe 2R0K · UniProt Q04756
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