Research workbench
Crystal structure of ALIX/AIP1 in complex with the HIV-1 ypltsl late domain
Analyse Crystal structure of ALIX/AIP1 in complex with the HIV-1 ypltsl late domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R02
- Type
- protein
- Length
- 708 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Programmed cell death 6-interacting protein; P6-gag
- UniProt
- Q8WUM4, Q9WC62
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Programmed cell death 6-interacting protein | protein | 697 | 71% helix, 2% strand | Q8WUM4 |
| B | P6-gag | protein | 11 | 45% helix, 0% strand | Q9WC62 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.65 | 0.86 | 26 | empty |
| 2 | 352 | 0.58 | 0.76 | 36 | empty |
| 3 | 242 | 0.54 | 0.76 | 25 | empty |
| 4 | 109 | 0.34 | 0.72 | 20 | empty |
| 5 | 62 | 0.30 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 582 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2R02 · Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLTSL Late Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WUM4 · AlphaFold monomer V2.0 prediction for programmed cell death 6-interacting protein (Q8WUM4) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WUM4
- Every structure of UniProt Q9WC62
- Elsewhere: RCSB PDB 2R02 · PDBe 2R02 · UniProt Q8WUM4 · UniProt Q9WC62
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