Research workbench
Crystal structure of aspartate semialdehyde dehydrogenase II from vibrio cholerae
Analyse Crystal structure of aspartate semialdehyde dehydrogenase II from vibrio… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QZ9
- Type
- protein
- Length
- 1,007 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aspartate-semialdehyde dehydrogenase
- EC
- 1.2.1.11
- UniProt
- P23247
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) | protein | 336 | 37% helix, 25% strand | P23247 |
| B | Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) | protein | 335 | 36% helix, 25% strand | P23247 |
Pockets
9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 333 | 0.74 | 0.86 | 45 | empty |
| 2 | 279 | 0.71 | 0.85 | 36 | empty |
| 3 | 167 | 0.66 | 0.86 | 31 | empty |
| 4 | 360 | 0.59 | 0.77 | 40 | empty |
| 5 | 71 | 0.53 | 0.87 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–C · 2357 Ų buried · 56 hydrogen bonds · protein-protein
- A–B · 1090 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 101 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2QZ9 · crystal structure of aspartate semialdehyde dehydrogenase II from vibrio cholerae · the same entry in another collection · chain A against A, TM-score 1.00
- P23247 · AlphaFold monomer V2.0 prediction for aspartate-semialdehyde dehydrogenase 2 (P23247) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23247
- Elsewhere: RCSB PDB 2QZ9 · PDBe 2QZ9 · UniProt P23247
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