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Crystal structure of mycobacterium tuberculosis leucine response regulatory protein (lrpa)

Analyse Crystal structure of mycobacterium tuberculosis leucine response regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QZ8
Type: protein
Length: 584 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable transcriptional regulatory protein
UniProt: P96896
Pockets: 8 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Probable transcriptional regulatory protein	protein	146	39% helix, 28% strand	P96896

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	192	0.64	0.84	33	empty
2	130	0.63	0.87	38	empty
3	182	0.59	0.82	35	empty
4	178	0.58	0.81	36	empty
5	70	0.39	0.79	20	empty

Interfaces

3 interfaces between chains.

A–D · 2844 Å² buried · 52 hydrogen bonds · protein-protein
B–D · 470 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 463 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2QZ8 · Crystal structure of Mycobacterium tuberculosis Leucine response regulatory protein (LrpA) · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt P96896
Elsewhere: RCSB PDB 2QZ8 · PDBe 2QZ8 · UniProt P96896

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