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Human RAF kinase inhibitor protein (rkip) in complex with O- phosphotyrosine

Analyse Human RAF kinase inhibitor protein (rkip) in complex with O- phosphotyrosine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QYQ
Type: protein
Length: 186 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphatidylethanolamine-binding protein 1
UniProt: P30086
Ligands: PTR
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphatidylethanolamine-binding protein 1	protein	186	13% helix, 30% strand	P30086

Ligands and binding sites

PTR · O-phosphotyrosine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.47	0.82	18	PTR

Compared structures

2QYQ · Human raf kinase inhibitor protein (rkip) in complex with o-phosphotyrosine · the same entry in another collection · chain A against A, TM-score 1.00
P30086 · AlphaFold monomer V2.0 prediction for phosphatidylethanolamine- binding protein 1 (P30086) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30086
Elsewhere: RCSB PDB 2QYQ · PDBe 2QYQ · UniProt P30086

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