Research workbench
Porcine liver fructose-1,6-bisphosphatase cocrystallized with fru-2,6- P2 and MG2+, I(T)-state
Analyse Porcine liver fructose-1,6-bisphosphatase cocrystallized with fru-2,6- P2 and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QVU
- Type
- protein
- Length
- 658 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-1,6-bisphosphatase 1
- EC
- 3.1.3.11
- UniProt
- P00636
- Ligands
- FDP, MG, PO4
- Pockets
- 8 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fructose-1,6-bisphosphatase 1 (EC 3.1.3.11) | protein | 329 | 37% helix, 24% strand | P00636 |
Ligands and binding sites
- FDP · 2,6-di-O-phosphono-beta-D-fructofuranose · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 4 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.52 | 0.80 | 34 | FDP, MG |
| 2 | 129 | 0.52 | 0.81 | 22 | empty |
| 3 | 147 | 0.51 | 0.80 | 41 | FDP |
| 4 | 218 | 0.50 | 0.75 | 32 | empty |
| 5 | 197 | 0.48 | 0.75 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 2412 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 2QVU · Porcine Liver Fructose-1,6-bisphosphatase cocrystallized with Fru-2,6-P2 and Mg2+… · the same entry in another collection · chain A against A, TM-score 1.00
- P00636 · AlphaFold monomer V2.0 prediction for fructose-1,6-bisphosphatase 1 (P00636) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00636
- Elsewhere: RCSB PDB 2QVU · PDBe 2QVU · UniProt P00636
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