Research workbench
Crystal structure of a disulfide trapped single chain trimer composed of the MHC I heavy chain H-2KB Y84C, beta-2MICROGLOBULIN, and ovalbumin-derived peptide.
Analyse Crystal structure of a disulfide trapped single chain trimer composed of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QRT
- Type
- protein
- Length
- 796 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H-2 class I histocompatibility antigen K-B alpha chain, beta-2 microglobulin…
- UniProt
- P01901, Q91XJ8
- Pockets
- 9 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | H-2 class I histocompatibility antigen K-B alpha chain, beta-2 microglobulin, ovalbumin-derived peptide | protein | 398 | 20% helix, 39% strand | P01901, Q91XJ8 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 719 | 0.66 | 0.75 | 64 | empty |
| 2 | 661 | 0.65 | 0.75 | 59 | empty |
| 3 | 229 | 0.59 | 0.80 | 31 | empty |
| 4 | 149 | 0.59 | 0.83 | 27 | empty |
| 5 | 182 | 0.56 | 0.80 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 254 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2QRT · Crystal Structure of a disulfide trapped single chain trimer composed of the MHC I heavy… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01901
- Every structure of UniProt Q91XJ8
- Elsewhere: RCSB PDB 2QRT · PDBe 2QRT · UniProt P01901 · UniProt Q91XJ8
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