Research workbench

Aeropyrum pernix acylaminoacyl peptidase, H367A mutant

Analyse Aeropyrum pernix acylaminoacyl peptidase, H367A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QR5
Type: protein
Length: 1,152 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acylamino-acid-releasing enzyme
EC: 3.4.19.1
UniProt: Q9YBQ2
Pockets: 10 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Acylamino-acid-releasing enzyme (EC 3.4.19.1)	protein	576	22% helix, 41% strand	Q9YBQ2

Pockets

10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1103	0.80	0.81	108	empty
2	79	0.76	0.98	16	empty
3	315	0.69	0.83	44	empty
4	454	0.68	0.80	41	empty
5	188	0.64	0.84	28	empty

Interfaces

1 interface between chains.

A–B · 1380 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

2QR5 · Aeropyrum pernix acylaminoacyl peptidase, H367A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q9YBQ2 · AlphaFold monomer V2.0 prediction for acylamino-acid-releasing enzyme (Q9YBQ2) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9YBQ2
Elsewhere: RCSB PDB 2QR5 · PDBe 2QR5 · UniProt Q9YBQ2

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