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Crystal structure of the putative rabgap domain of human TBC1 domain family member 14

Analyse Crystal structure of the putative rabgap domain of human TBC1 domain family… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QQ8
Type: protein
Length: 288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TBC1 domain family member 14
UniProt: Q9P2M4
Ligands: UNX
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TBC1 domain family member 14	protein	288	69% helix, 1% strand	Q9P2M4

Ligands and binding sites

UNX · Unknown atom or ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.40	0.75	23	UNX
2	55	0.35	0.78	15	empty

Compared structures

2QQ8 · Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14 · the same entry in another collection · chain A against A, TM-score 1.00
Q9P2M4 · AlphaFold monomer V2.0 prediction for TBC1 domain family member 14 (Q9P2M4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9P2M4
Elsewhere: RCSB PDB 2QQ8 · PDBe 2QQ8 · UniProt Q9P2M4

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