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Human EPHA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant

Analyse Human EPHA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QOO
Type: protein
Length: 273 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin receptor
EC: 2.7.10.1
UniProt: Q6P4R6
Pockets: 1 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin receptor (EC 2.7.10.1)	protein	273	41% helix, 18% strand	Q6P4R6

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	315	0.57	0.76	35	empty

Compared structures

2QOO · Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P4R6
Elsewhere: RCSB PDB 2QOO · PDBe 2QOO · UniProt Q6P4R6

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