Research workbench
Crystal structure of transcription factor PF0095 from pyrococcus furiosus
Analyse Crystal structure of transcription factor PF0095 from pyrococcus furiosus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QLZ
- Type
- protein
- Length
- 868 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor PF0095
- UniProt
- Q8U4J2
- Pockets
- 9 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription factor PF0095 | protein | 219 | 48% helix, 20% strand | Q8U4J2 |
| B | Transcription factor PF0095 | protein | 220 | 48% helix, 18% strand | Q8U4J2 |
| C | Transcription factor PF0095 | protein | 213 | 49% helix, 18% strand | Q8U4J2 |
| D | Transcription factor PF0095 | protein | 216 | 51% helix, 19% strand | Q8U4J2 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 410 | 0.63 | 0.78 | 41 | empty |
| 2 | 340 | 0.58 | 0.76 | 32 | empty |
| 3 | 255 | 0.57 | 0.78 | 38 | empty |
| 4 | 206 | 0.52 | 0.77 | 20 | empty |
| 5 | 131 | 0.47 | 0.78 | 21 | empty |
Interfaces
5 interfaces between chains.
- A–B · 4191 Ų buried · 59 hydrogen bonds · protein-protein
- C–D · 4190 Ų buried · 62 hydrogen bonds · protein-protein
- B–D · 539 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 167 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 75 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 30 modified, 4 disulfide (engineered, disulfide).
Compared structures
- 2QLZ · Crystal Structure of Transcription Factor PF0095 from Pyrococcus furiosus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U4J2
- Elsewhere: RCSB PDB 2QLZ · PDBe 2QLZ · UniProt Q8U4J2
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