Research workbench
Human liver glycogen phosphorylase- gl complex
Analyse Human liver glycogen phosphorylase- gl complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QLL
- Type
- protein
- Length
- 810 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen phosphorylase, liver form; Protein targeting to glycogen - gl
- EC
- 2.4.1.1
- UniProt
- P06737
- Ligands
- PLP
- Pockets
- 11 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycogen phosphorylase, liver form (EC 2.4.1.1) | protein | 806 | 50% helix, 13% strand | P06737 |
| B | Protein targeting to glycogen - gl | protein | 4 | 0% helix, 0% strand | — |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 881 | 0.79 | 0.81 | 75 | PLP |
| 2 | 96 | 0.70 | 0.93 | 26 | empty |
| 3 | 284 | 0.62 | 0.80 | 31 | empty |
| 4 | 249 | 0.58 | 0.79 | 42 | empty |
| 5 | 69 | 0.45 | 0.82 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 382 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06737
- Elsewhere: RCSB PDB 2QLL · PDBe 2QLL · UniProt P06737
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