Research workbench
The crystal structure of DNA repair protein radc from chlorobium tepidum tls
Analyse The crystal structure of DNA repair protein radc from chlorobium tepidum tls in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QLC
- Type
- protein
- Length
- 995 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein radc homolog
- UniProt
- Q8KES1
- Pockets
- 13 · best druggability 0.54
Structure
x-ray diffraction · 5 distinct chains · 32% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F | DNA repair protein radc homolog | protein | 126 | 30% helix, 29% strand | Q8KES1 |
| B | DNA repair protein radc homolog | protein | 124 | 33% helix, 28% strand | Q8KES1 |
| C | DNA repair protein radc homolog | protein | 125 | 30% helix, 29% strand | Q8KES1 |
| D | DNA repair protein radc homolog | protein | 122 | 34% helix, 27% strand | Q8KES1 |
| E, G, H | DNA repair protein radc homolog | protein | 124 | 31% helix, 28% strand | Q8KES1 |
Pockets
13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.54 | 0.75 | 54 | empty |
| 2 | 121 | 0.44 | 0.77 | 21 | empty |
| 3 | 178 | 0.43 | 0.74 | 35 | empty |
| 4 | 76 | 0.40 | 0.78 | 17 | empty |
| 5 | 104 | 0.40 | 0.76 | 22 | empty |
Interfaces
12 interfaces between chains.
- C–F · 679 Ų buried · 5 hydrogen bonds · protein-protein
- B–E · 672 Ų buried · 2 hydrogen bonds · protein-protein
- A–G · 663 Ų buried · 4 hydrogen bonds · protein-protein
- D–H · 645 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 485 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2QLC · The crystal structure of DNA repair protein RadC from Chlorobium tepidum TLS · the same entry in another collection · chain H against H, TM-score 1.00
- Q8KES1 · AlphaFold monomer V2.0 prediction for UPF0758 protein CT0611 (Q8KES1) · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8KES1
- Elsewhere: RCSB PDB 2QLC · PDBe 2QLC · UniProt Q8KES1
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