Research workbench

Crystal structure of the ING1 phd finger in complex with a histone H3K4ME3 peptide

Analyse Crystal structure of the ING1 phd finger in complex with a histone H3K4ME3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QIC
Type: protein
Length: 59 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inhibitor of growth protein 1; H3K4ME3 peptide
UniProt: Q9UK53
Ligands: ZN

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inhibitor of growth protein 1	protein	51	14% helix, 22% strand	Q9UK53
B	H3K4ME3 peptide	protein	8	0% helix, 50% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 555 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

2QIC · Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q9UK53 · AlphaFold monomer V2.0 prediction for inhibitor of growth protein 1 (Q9UK53) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UK53
Elsewhere: RCSB PDB 2QIC · PDBe 2QIC · UniProt Q9UK53

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.