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Crystal structure of mannose-6-phosphate isomerase from helicobacter pylori

Analyse Crystal structure of mannose-6-phosphate isomerase from helicobacter pylori in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QH5
Type: protein
Length: 509 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mannose-6-phosphate isomerase
UniProt: O24884
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mannose-6-phosphate isomerase	protein	253	37% helix, 27% strand	O24884
B	Mannose-6-phosphate isomerase	protein	256	35% helix, 26% strand	O24884

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.65	0.84	27	empty
2	269	0.56	0.77	31	empty
3	251	0.55	0.77	34	empty
4	105	0.41	0.77	17	empty
5	78	0.37	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 427 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

2QH5 · Crystal structure of mannose-6-phosphate isomerase from Helicobacter pylori · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O24884
Elsewhere: RCSB PDB 2QH5 · PDBe 2QH5 · UniProt O24884

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