Research workbench
Crystal structure of human nicotinamide riboside kinase (NRK1) in complex with nicotinamide mononucleotide (nmn)
Analyse Crystal structure of human nicotinamide riboside kinase (NRK1) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QG6
- Type
- protein
- Length
- 182 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nicotinamide riboside kinase 1
- EC
- 2.7.1.-
- UniProt
- Q9NWW6
- Ligands
- NMN, PO4
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicotinamide riboside kinase 1 (EC 2.7.1.-) | protein | 182 | 47% helix, 17% strand | Q9NWW6 |
Ligands and binding sites
- NMN · Beta-nicotinamide ribose monophosphate · ligand · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.59 | 0.83 | 24 | PO4, NMN |
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 2QG6 · Crystal structure of human nicotinamide riboside kinase (NRK1) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NWW6 · AlphaFold monomer V2.0 prediction for nicotinamide riboside kinase 1 (Q9NWW6) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWW6
- Elsewhere: RCSB PDB 2QG6 · PDBe 2QG6 · UniProt Q9NWW6
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