Research workbench
Crystal structure of first two rrm domains of fir bound to ssdna from a portion of fuse
Analyse Crystal structure of first two rrm domains of fir bound to ssdna from a portion… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QFJ
- Type
- protein + DNA
- Length
- 389 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DT…
- UniProt
- Q9NZA0
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | DNA (5'- D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DT P*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3') | dna | 2 | — | — |
| A | Fbp-interacting repressor | protein | 193 | 34% helix, 25% strand | Q9NZA0 |
| B | Fbp-interacting repressor | protein | 194 | 34% helix, 25% strand | Q9NZA0 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1040 | 0.72 | 0.76 | 94 | empty |
| 2 | 82 | 0.32 | 0.74 | 20 | empty |
| 3 | 72 | 0.29 | 0.73 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 565 Ų buried · 12 hydrogen bonds · protein-protein
- C–B · 244 Ų buried · 1 hydrogen bond · protein-nucleic
- C–A · 208 Ų buried · 4 hydrogen bonds · protein-nucleic
Compared structures
- 2QFJ · Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZA0
- Elsewhere: RCSB PDB 2QFJ · PDBe 2QFJ · UniProt Q9NZA0
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