Research workbench
Fv fragment of mouse monoclonal antibody D1.3 (BALB/C, IGG1, K) variant chain L GLU81->asp
Analyse Fv fragment of mouse monoclonal antibody D1.3 (BALB/C, IGG1, K) variant chain L… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1A7R
- Type
- protein
- Length
- 223 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1-kappa D1.3 fv (light chain); IGG1-kappa D1.3 fv (heavy chain)
- UniProt
- P01635, P01820
- Pockets
- 1 · best druggability 0.29
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG1-kappa D1.3 fv (light chain) | protein | 107 | 3% helix, 50% strand | P01635 |
| H | IGG1-kappa D1.3 fv (heavy chain) | protein | 116 | 5% helix, 52% strand | P01820 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.29 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- L–H · 896 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1A7R · Fv fragment of mouse monoclonal antibody D1.3 (BALB/C, IGG1, K) variant chain L GLU81->asp · the same entry in another collection · chain L against L, TM-score 1.00
- P01635 · AlphaFold monomer V2.0 prediction for ig kappa chain V-V region K2 (P01635) · a predicted model of the same protein · chain L against A, TM-score 0.87
- P01820 · AlphaFold monomer V2.0 prediction for ig heavy chain V region PJ14 (P01820) · a predicted model of the same protein · chain H against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01635
- Every structure of UniProt P01820
- Elsewhere: RCSB PDB 1A7R · PDBe 1A7R · UniProt P01635 · UniProt P01820
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