Research workbench
Ensemble refinement of the protein crystal structure of gene product from arabidopsis thaliana AT2G19940
Analyse Ensemble refinement of the protein crystal structure of gene product from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Q49
- Type
- protein
- Length
- 1,380 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable N-acetyl-gamma-glutamyl-phosphate reductase
- EC
- 1.2.1.38
- UniProt
- Q93Z70
- Pockets
- 14 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Probable N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) | protein | 345 | 33% helix, 21% strand | Q93Z70 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.75 | 0.99 | 13 | empty |
| 2 | 62 | 0.74 | 0.99 | 13 | empty |
| 3 | 700 | 0.70 | 0.77 | 68 | empty |
| 4 | 729 | 0.70 | 0.77 | 79 | empty |
| 5 | 740 | 0.70 | 0.77 | 74 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2139 Ų buried · 45 hydrogen bonds · protein-protein
- A–D · 2123 Ų buried · 37 hydrogen bonds · protein-protein
- A–B · 1561 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1515 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 901 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2Q49 · Ensemble refinement of the protein crystal structure of gene product from Arabidopsis… · the same entry in another collection · chain D against D, TM-score 1.00
- Q93Z70 · AlphaFold monomer V2.0 prediction for probable N-acetyl-gamma- glutamyl-phosphate… · a predicted model of the same protein · chain D against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q93Z70
- Elsewhere: RCSB PDB 2Q49 · PDBe 2Q49 · UniProt Q93Z70
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