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Crystal structure of the D10-P3/IQN17 complex: a D-peptide inhibitor of HIV-1 entry bound to the GP41 coiled-coil pocket
Analyse Crystal structure of the D10-P3/IQN17 complex: a D-peptide inhibitor of HIV-1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Q3I
- Type
- protein
- Length
- 61 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein between the coiled-coil pocket of HIV GP41 and GCN4-piqi; D-peptide
- UniProt
- A3F986
- Ligands
- ACE, CL
Structure
x-ray diffraction · 2 distinct chains · 89% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein between the coiled-coil pocket of HIV GP41 and GCN4-piqi | protein | 45 | 96% helix, 0% strand | A3F986 |
| D | D-peptide | protein | 16 | 69% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–D · 321 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 d-amino, 2 covalent (D-amino acid, covalent ligand).
Compared structures
- 2Q3I · Crystal structure of the D10-P3/IQN17 complex: a D-peptide inhibitor of HIV-1 entry bound… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3F986
- Elsewhere: RCSB PDB 2Q3I · PDBe 2Q3I · UniProt A3F986
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