Research workbench
Protein-RNA interaction involving KH1 domain from human POLY(C)-binding protein-2
Analyse Protein-RNA interaction involving KH1 domain from human POLY(C)-binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PY9
- Type
- protein + RNA
- Length
- 303 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 12-mer C-rich strand of human telomeric RNA; POLY(RC)-binding protein 2
- UniProt
- Q15366
Structure
x-ray diffraction · 3 distinct chains · 52% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F | 12-mer C-rich strand of human telomeric RNA | rna | 12 | — | — |
| A | POLY(RC)-binding protein 2 | protein | 72 | 50% helix, 31% strand | Q15366 |
| B, C, D | POLY(RC)-binding protein 2 | protein | 69 | 54% helix, 29% strand | Q15366 |
Interfaces
6 interfaces between chains.
- A–B · 948 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 882 Ų buried · 6 hydrogen bonds · protein-protein
- F–C · 642 Ų buried · 17 hydrogen bonds · protein-nucleic
- E–B · 541 Ų buried · 17 hydrogen bonds · protein-nucleic
- F–A · 530 Ų buried · 18 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 2PY9 · Protein-RNA Interaction involving KH1 domain from Human Poly(C)-Binding Protein-2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q15366 · AlphaFold monomer V2.0 prediction for POLY(RC)-binding protein 2 (Q15366) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15366
- Elsewhere: RCSB PDB 2PY9 · PDBe 2PY9 · UniProt Q15366
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