Research workbench
Variant 8 of ribonucleoprotein core of the E. COLI signal recognition particle
Analyse Variant 8 of ribonucleoprotein core of the E. COLI signal recognition particle in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PXK
- Type
- protein + RNA
- Length
- 118 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4.5 S RNA; Signal recognition particle protein
- UniProt
- P0AGD7
- Ligands
- NCO
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 4.5 S RNA | rna | 49 | — | — |
| A | Signal recognition particle protein | protein | 69 | 62% helix, 0% strand | P0AGD7 |
Ligands and binding sites
- NCO · Cobalt hexammine(iii) · ligand · 7 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 591 | 0.62 | 0.75 | 37 | NCO |
Interfaces
1 interface between chains.
- B–A · 632 Ų buried · 23 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 2PXK · Variant 8 of Ribonucleoprotein Core of the E. Coli Signal Recognition Particle · the same entry in another collection · chain B against B, TM-score 1.00
- P0AGD7 · AlphaFold monomer V2.0 prediction for signal recognition particle protein (P0AGD7) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AGD7
- Elsewhere: RCSB PDB 2PXK · PDBe 2PXK · UniProt P0AGD7
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