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Porcine pancreatic spasmolytic polypeptide

Analyse Porcine pancreatic spasmolytic polypeptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PSP
Type: protein
Length: 212 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Porcine pancreatic spasmolytic polypeptide
UniProt: P01359
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Porcine pancreatic spasmolytic polypeptide	protein	106	27% helix, 9% strand	P01359

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.53	0.81	24	empty
2	117	0.49	0.80	23	empty

Interfaces

1 interface between chains.

A–B · 822 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 14 disulfide, 2 modified (disulfide, cyclization).

Compared structures

2PSP · Porcine pancreatic spasmolytic polypeptide · the same entry in another collection · chain A against A, TM-score 1.00
P01359 · AlphaFold monomer V2.0 prediction for trefoil factor 2 (P01359) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01359
Elsewhere: RCSB PDB 2PSP · PDBe 2PSP · UniProt P01359

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