Research workbench
Structure and metal binding properties of znua, a periplasmic zinc transporter from escherichia COLI
Analyse Structure and metal binding properties of znua, a periplasmic zinc transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PS0
- Type
- protein
- Length
- 527 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- High-affinity zinc uptake system protein znua
- UniProt
- P39172
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | High-affinity zinc uptake system protein znua | protein | 264 | 51% helix, 11% strand | P39172 |
| B | High-affinity zinc uptake system protein znua | protein | 263 | 50% helix, 12% strand | P39172 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 699 | 0.67 | 0.76 | 67 | empty |
| 2 | 75 | 0.39 | 0.78 | 19 | empty |
| 3 | 63 | 0.30 | 0.75 | 17 | empty |
| 4 | 67 | 0.30 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 456 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2PS0 · Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from… · the same entry in another collection · chain A against A, TM-score 1.00
- P39172 · AlphaFold monomer V2.0 prediction for high-affinity zinc uptake system protein znua… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39172
- Elsewhere: RCSB PDB 2PS0 · PDBe 2PS0 · UniProt P39172
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