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Crystal structure of MUTT/NUDIX family protein from streptococcus pneumoniae

Analyse Crystal structure of MUTT/NUDIX family protein from streptococcus pneumoniae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PQV
Type: protein
Length: 302 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MUTT/NUDIX family protein
UniProt: Q97T37
Ligands: PO4
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MUTT/NUDIX family protein	protein	150	15% helix, 53% strand	Q97T37
B	MUTT/NUDIX family protein	protein	152	15% helix, 53% strand	Q97T37

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.55	0.76	33	empty
2	212	0.51	0.76	33	empty

Interfaces

1 interface between chains.

A–B · 1246 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

2PQV · Crystal structure of MutT/nudix family protein from Streptococcus pneumoniae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q97T37
Elsewhere: RCSB PDB 2PQV · PDBe 2PQV · UniProt Q97T37

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