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Crystal structure of KH1 domain of human PCBP2 complexed to single- stranded 12-mer telomeric DNA
Analyse Crystal structure of KH1 domain of human PCBP2 complexed to single- stranded… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PQU
- Type
- protein + DNA
- Length
- 306 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 12-mer C-rich strand of human telomeric DNA; POLY(RC)-binding protein 2
- UniProt
- Q15366
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, G | 12-mer C-rich strand of human telomeric DNA | dna | 12 | — | — |
| A | POLY(RC)-binding protein 2 | protein | 72 | 50% helix, 31% strand | Q15366 |
| B, C, D | POLY(RC)-binding protein 2 | protein | 70 | 53% helix, 26% strand | Q15366 |
Interfaces
6 interfaces between chains.
- A–B · 1005 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 934 Ų buried · 13 hydrogen bonds · protein-protein
- E–C · 647 Ų buried · 16 hydrogen bonds · protein-nucleic
- G–B · 528 Ų buried · 13 hydrogen bonds · protein-nucleic
- E–A · 511 Ų buried · 12 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 2PQU · Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer… · the same entry in another collection · chain D against D, TM-score 1.00
- Q15366 · AlphaFold monomer V2.0 prediction for POLY(RC)-binding protein 2 (Q15366) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15366
- Elsewhere: RCSB PDB 2PQU · PDBe 2PQU · UniProt Q15366
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