Research workbench
Crystal structure of yeast FIS1 complexed with a fragment of yeast CAF4
Analyse Crystal structure of yeast FIS1 complexed with a fragment of yeast CAF4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PQR
- Type
- protein
- Length
- 307 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondria fission 1 protein; Wd repeat protein YKR036C
- UniProt
- P40515, P36130
- Ligands
- AU
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondria fission 1 protein | protein | 98 | 79% helix, 0% strand | P40515 |
| B | Mitochondria fission 1 protein | protein | 124 | 80% helix, 0% strand | P40515 |
| C | Wd repeat protein YKR036C | protein | 40 | 45% helix, 0% strand | P36130 |
| D | Wd repeat protein YKR036C | protein | 45 | 44% helix, 0% strand | P36130 |
Ligands and binding sites
- AU · Gold ion · metal · 2 copies · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 414 | 0.73 | 0.84 | 60 | empty |
| 2 | 52 | 0.35 | 0.79 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–D · 1651 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 1574 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 330 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 295 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 260 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2PQR · Crystal structure of yeast Fis1 complexed with a fragment of yeast Caf4 · the same entry in another collection · chain D against D, TM-score 1.00
- P40515 · AlphaFold monomer V2.0 prediction for mitochondrial fission 1 protein (P40515) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P36130 · AlphaFold monomer V2.0 prediction for CCR4-associated factor 4 (P36130) · a predicted model of the same protein · chain D against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40515
- Every structure of UniProt P36130
- Elsewhere: RCSB PDB 2PQR · PDBe 2PQR · UniProt P40515 · UniProt P36130
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.