Research workbench
Crystal structure of dual specificity protein phosphatase 13 (DUSP13)
Analyse Crystal structure of dual specificity protein phosphatase 13 (DUSP13) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PQ5
- Type
- protein
- Length
- 675 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity protein phosphatase 13
- EC
- 3.1.3.48, 3.1.3.16
- UniProt
- Q9UII6
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Dual specificity protein phosphatase 13 (EC 3.1.3.48, 3.1.3.16) | protein | 169 | 46% helix, 15% strand | Q9UII6 |
| B | Dual specificity protein phosphatase 13 (EC 3.1.3.48, 3.1.3.16) | protein | 168 | 44% helix, 13% strand | Q9UII6 |
| C | Dual specificity protein phosphatase 13 (EC 3.1.3.48, 3.1.3.16) | protein | 169 | 43% helix, 14% strand | Q9UII6 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1023 | 0.82 | 0.83 | 114 | empty |
| 2 | 621 | 0.81 | 0.86 | 89 | empty |
| 3 | 228 | 0.57 | 0.79 | 32 | empty |
| 4 | 64 | 0.48 | 0.85 | 14 | empty |
Interfaces
6 interfaces between chains.
- A–D · 971 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 954 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 543 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 267 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 120 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2PQ5 · Crystal structure of Dual specificity protein phosphatase 13 (DUSP13) · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UII6 · AlphaFold monomer V2.0 prediction for dual specificity protein phosphatase 13 isoform B… · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UII6
- Elsewhere: RCSB PDB 2PQ5 · PDBe 2PQ5 · UniProt Q9UII6
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