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Solution structure of human MEKK3 PB1 domain

Analyse Solution structure of human MEKK3 PB1 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PPH
Type: protein
Length: 93 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase kinase kinase 3
EC: 2.7.11.25
UniProt: Q99759
Pockets: 1 · best druggability 0.44

Structure

solution nmr · 1 distinct chain · 27% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25)	protein	93	27% helix, 32% strand	Q99759

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.44	0.83	24	empty

Compared structures

2PPH · solution structure of human MEKK3 PB1 domain · the same entry in another collection · chain A against A, TM-score 1.00
Q99759 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 3… · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99759
Elsewhere: RCSB PDB 2PPH · PDBe 2PPH · UniProt Q99759

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