Research workbench

E.COLI response regulator phop receiver domain

Analyse E.COLI response regulator phop receiver domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PKX
Type: protein
Length: 239 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulatory protein phop
UniProt: P23836
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulatory protein phop	protein	119	48% helix, 20% strand	P23836
B	Transcriptional regulatory protein phop	protein	120	48% helix, 20% strand	P23836

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.38	0.76	22	empty

Interfaces

1 interface between chains.

A–B · 965 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

2PKX · E.coli response regulator PhoP receiver domain · the same entry in another collection · chain A against A, TM-score 1.00
P23836 · AlphaFold monomer V2.0 prediction for transcriptional regulatory protein phop (P23836) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23836
Elsewhere: RCSB PDB 2PKX · PDBe 2PKX · UniProt P23836

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.