Research workbench

E. COLI lytic transglycosylase mlta-D308A in apo-2 form

Analyse E. COLI lytic transglycosylase mlta-D308A in apo-2 form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PIC
Type: protein
Length: 336 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Membrane-bound lytic murein transglycosylase a
EC: 3.2.1.-
UniProt: P0A935
Pockets: 6 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Membrane-bound lytic murein transglycosylase a (EC 3.2.1.-)	protein	336	28% helix, 30% strand	P0A935

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	174	0.48	0.76	25	empty
2	78	0.47	0.82	24	empty
3	59	0.38	0.80	16	empty
4	59	0.34	0.77	15	empty
5	62	0.31	0.75	14	empty

Compared structures

2PIC · E. coli lytic transglycosylase MltA-D308A in apo-2 form · the same entry in another collection · chain A against A, TM-score 1.00
P0A935 · AlphaFold monomer V2.0 prediction for membrane-bound lytic murein transglycosylase a… · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A935
Elsewhere: RCSB PDB 2PIC · PDBe 2PIC · UniProt P0A935

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