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Crystal structure of 3-oxoacyl-[acyl carrier protein] reductase TTHA0415 from thermus thermophilus
Analyse Crystal structure of 3-oxoacyl-[acyl carrier protein] reductase TTHA0415 from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PH3
- Type
- protein
- Length
- 482 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-oxoacyl-[acyl carrier protein] reductase
- EC
- 1.1.1.100
- UniProt
- Q5SL78
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-oxoacyl-[acyl carrier protein] reductase (EC 1.1.1.100) | protein | 245 | 51% helix, 17% strand | Q5SL78 |
| B | 3-oxoacyl-[acyl carrier protein] reductase (EC 1.1.1.100) | protein | 237 | 54% helix, 14% strand | Q5SL78 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 639 | 0.77 | 0.83 | 52 | empty |
| 2 | 626 | 0.71 | 0.79 | 61 | empty |
| 3 | 111 | 0.55 | 0.83 | 19 | empty |
| 4 | 56 | 0.36 | 0.79 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1708 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 2PH3 · Crystal structure of 3-oxoacyl-[acyl carrier protein] reductase TTHA0415 from Thermus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SL78
- Elsewhere: RCSB PDB 2PH3 · PDBe 2PH3 · UniProt Q5SL78
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