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Crystal structure of human procathepsin B at 3.3 ångström resolution

Analyse Crystal structure of human procathepsin B at 3.3 ångström resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PBH
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procathepsin B
EC: 3.4.22.1
UniProt: P07858
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Procathepsin B (EC 3.4.22.1)	protein	317	25% helix, 20% strand	P07858

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.29	0.74	15	empty
2	61	0.27	0.73	15	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2PBH · Crystal structure of human procathepsin B at 3.3 ångström resolution · the same entry in another collection · chain A against A, TM-score 1.00
P07858 · AlphaFold monomer V2.0 prediction for cathepsin B (P07858) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07858
Elsewhere: RCSB PDB 2PBH · PDBe 2PBH · UniProt P07858

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