Research workbench
Crystal structure of the SERINE/THREONINE phosphatase domain of human PPM1B
Analyse Crystal structure of the SERINE/THREONINE phosphatase domain of human PPM1B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2P8E
- Type
- protein
- Length
- 559 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PPM1B beta isoform variant 6
- EC
- 3.1.3.16
- UniProt
- Q4J6C0
- Ligands
- MG
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PPM1B beta isoform variant 6 (EC 3.1.3.16) | protein | 278 | 29% helix, 35% strand | Q4J6C0 |
| B | PPM1B beta isoform variant 6 (EC 3.1.3.16) | protein | 281 | 31% helix, 35% strand | Q4J6C0 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.40 | 0.76 | 23 | empty |
| 2 | 123 | 0.40 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 25 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 2P8E · Crystal structure of the serine/threonine phosphatase domain of human PPM1B · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4J6C0
- Elsewhere: RCSB PDB 2P8E · PDBe 2P8E · UniProt Q4J6C0
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