Research workbench

Human dead-box RNA helicase DDX41, helicase domain

Analyse Human dead-box RNA helicase DDX41, helicase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2P6N
Type: protein
Length: 318 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase DDX41
EC: 3.6.1.-
UniProt: Q9UJV9
Pockets: 2 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase DDX41 (EC 3.6.1.-)	protein	160	43% helix, 18% strand	Q9UJV9
B	ATP-dependent RNA helicase DDX41 (EC 3.6.1.-)	protein	158	42% helix, 19% strand	Q9UJV9

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.31	0.76	15	empty
2	69	0.31	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 555 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2P6N · Human DEAD-box RNA helicase DDX41, helicase domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9UJV9 · AlphaFold monomer V2.0 prediction for probable ATP-dependent RNA helicase DDX41 (Q9UJV9) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UJV9
Elsewhere: RCSB PDB 2P6N · PDBe 2P6N · UniProt Q9UJV9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.