Research workbench
The structure of the ACTIVIN:FOLLISTATIN 315 complex
Analyse The structure of the ACTIVIN:FOLLISTATIN 315 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2P6A
- Type
- protein
- Length
- 816 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inhibin beta a chain; Follistatin; Probable fragment of follistatin
- UniProt
- P08476, P19883
- Pockets
- 17 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 16% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Inhibin beta a chain | protein | 116 | 23% helix, 34% strand | P08476 |
| D | Follistatin | protein | 292 | 15% helix, 20% strand | P19883 |
| C | Follistatin | protein | 282 | 15% helix, 22% strand | P19883 |
| E | Probable fragment of follistatin | protein | 10 | 0% helix, 0% strand | — |
Pockets
17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1112 | 0.79 | 0.81 | 107 | empty |
| 2 | 879 | 0.74 | 0.78 | 90 | empty |
| 3 | 163 | 0.68 | 0.87 | 25 | empty |
| 4 | 69 | 0.66 | 0.93 | 18 | empty |
| 5 | 307 | 0.64 | 0.80 | 45 | empty |
Interfaces
8 interfaces between chains.
- A–B · 1430 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1355 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 1289 Ų buried · 11 hydrogen bonds · protein-protein
- D–C · 640 Ų buried · 25 hydrogen bonds · protein-protein
- D–B · 326 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 disulfide (disulfide).
Compared structures
- 2P6A · The structure of the Activin:Follistatin 315 complex · the same entry in another collection · chain E against E, TM-score 1.00
- P19883 · AlphaFold monomer V2.0 prediction for follistatin (P19883) · a predicted model of the same protein · chain C against A, TM-score 0.95
- P08476 · AlphaFold monomer V2.0 prediction for inhibin beta a chain (P08476) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08476
- Every structure of UniProt P19883
- Elsewhere: RCSB PDB 2P6A · PDBe 2P6A · UniProt P08476 · UniProt P19883
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