Research workbench
Crystal structure of maf domain of human N-acetylserotonin O- methyltransferase-like protein
Analyse Crystal structure of maf domain of human N-acetylserotonin O… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2P5X
- Type
- protein
- Length
- 405 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acetylserotonin O-methyltransferase-like protein
- UniProt
- O95671
- Ligands
- PO4
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acetylserotonin O-methyltransferase-like protein | protein | 204 | 42% helix, 28% strand | O95671 |
| B | N-acetylserotonin O-methyltransferase-like protein | protein | 201 | 37% helix, 26% strand | O95671 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 339 | 0.62 | 0.78 | 43 | PO4 |
| 2 | 230 | 0.52 | 0.76 | 24 | empty |
| 3 | 109 | 0.48 | 0.81 | 22 | PO4 |
| 4 | 75 | 0.43 | 0.81 | 19 | empty |
| 5 | 107 | 0.38 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 919 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2P5X · Crystal structure of Maf domain of human N-acetylserotonin O-methyltransferase-like… · the same entry in another collection · chain A against A, TM-score 1.00
- O95671 · AlphaFold monomer V2.0 prediction for probable bifunctional DTTP/UTP… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95671
- Elsewhere: RCSB PDB 2P5X · PDBe 2P5X · UniProt O95671
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