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Crystal structure of phosphoribosyltransferase from corynebacterium diphtheriae

Analyse Crystal structure of phosphoribosyltransferase from corynebacterium diphtheriae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2P1Z
Type: protein
Length: 326 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoribosyltransferase
EC: 2.4.2.10
UniProt: Q6NF12
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoribosyltransferase (EC 2.4.2.10)	protein	158	37% helix, 22% strand	Q6NF12
B	Phosphoribosyltransferase (EC 2.4.2.10)	protein	168	38% helix, 23% strand	Q6NF12

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	273	0.55	0.76	33	empty
2	262	0.53	0.76	30	empty

Interfaces

1 interface between chains.

A–B · 1470 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

2P1Z · Crystal structure of phosphoribosyltransferase from Corynebacterium diphtheriae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6NF12
Elsewhere: RCSB PDB 2P1Z · PDBe 2P1Z · UniProt Q6NF12

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