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Crystal structure of bacterial regulatory protein of gntr family from corynebacterium glutamicum

Analyse Crystal structure of bacterial regulatory protein of gntr family from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2P19
Type: protein
Length: 438 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator
UniProt: Q8NTZ4
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 20% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator	protein	148	19% helix, 46% strand	Q8NTZ4
B	Transcriptional regulator	protein	142	19% helix, 44% strand	Q8NTZ4
C	Transcriptional regulator	protein	148	22% helix, 46% strand	Q8NTZ4

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.59	0.83	25	empty
2	261	0.54	0.76	28	empty
3	129	0.43	0.76	18	empty
4	122	0.40	0.74	17	empty

Interfaces

2 interfaces between chains.

A–C · 1222 Å² buried · 25 hydrogen bonds · protein-protein
A–B · 674 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

2P19 · Crystal structure of bacterial regulatory protein of gntR family from Corynebacterium… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NTZ4
Elsewhere: RCSB PDB 2P19 · PDBe 2P19 · UniProt Q8NTZ4

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