Research workbench
Motor domain of neurospora crassa kinesin-3 (NCKIN3)
Analyse Motor domain of neurospora crassa kinesin-3 (NCKIN3) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OWM
- Type
- protein
- Length
- 1,308 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Related to kinesin-like protein KIF1C
- EC
- 3.6.4.4
- UniProt
- Q9C2M3
- Ligands
- ADP, MG
- Pockets
- 13 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 28% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Related to kinesin-like protein KIF1C (EC 3.6.4.4) | protein | 328 | 27% helix, 28% strand | Q9C2M3 |
| B | Related to kinesin-like protein KIF1C (EC 3.6.4.4) | protein | 327 | 29% helix, 29% strand | Q9C2M3 |
| D | Related to kinesin-like protein KIF1C (EC 3.6.4.4) | protein | 325 | 29% helix, 29% strand | Q9C2M3 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 4 copies · chains A, C, B, D
- MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1147 | 0.80 | 0.81 | 94 | MG, ADP |
| 2 | 756 | 0.79 | 0.83 | 72 | empty |
| 3 | 1171 | 0.76 | 0.78 | 98 | MG, ADP |
| 4 | 190 | 0.57 | 0.80 | 30 | empty |
| 5 | 171 | 0.54 | 0.79 | 24 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1676 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 1597 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1030 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2OWM · Motor domain of Neurospora crassa kinesin-3 (NcKin3) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C2M3
- Elsewhere: RCSB PDB 2OWM · PDBe 2OWM · UniProt Q9C2M3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.