Research workbench
Progesterone receptor with bound asoprisnil and a peptide from the co- repressor smrt
Analyse Progesterone receptor with bound asoprisnil and a peptide from the co… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OVH
- Type
- protein
- Length
- 256 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Progesterone receptor; Smrt peptide
- UniProt
- P06401
- Ligands
- AS0
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Progesterone receptor | protein | 243 | 67% helix, 5% strand | P06401 |
| B | Smrt peptide | protein | 13 | 77% helix, 0% strand | — |
Ligands and binding sites
- AS0 · 4-[(11beta,17beta)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl]benzaldehyde oxime · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.78 | 0.84 | 52 | AS0 |
| 2 | 219 | 0.71 | 0.87 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 532 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2OVH · Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT · the same entry in another collection · chain A against A, TM-score 1.00
- P06401 · AlphaFold monomer V2.0 prediction for progesterone receptor (P06401) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06401
- Elsewhere: RCSB PDB 2OVH · PDBe 2OVH · UniProt P06401
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