Research workbench
Crystal structure of a N-terminal fragment of skap-hom containing both the helical dimerization domain and the pH domain
Analyse Crystal structure of a N-terminal fragment of skap-hom containing both the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OTX
- Type
- protein
- Length
- 338 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Src kinase-associated phosphoprotein 2
- UniProt
- Q3UND0
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Src kinase-associated phosphoprotein 2 | protein | 170 | 41% helix, 25% strand | Q3UND0 |
| B | Src kinase-associated phosphoprotein 2 | protein | 168 | 39% helix, 26% strand | Q3UND0 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 400 | 0.61 | 0.77 | 35 | empty |
| 2 | 264 | 0.57 | 0.78 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 1219 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2OTX · Crystal Structure of A N-terminal Fragment of SKAP-HOM Containing both the Helical… · the same entry in another collection · chain A against A, TM-score 1.00
- Q3UND0 · AlphaFold monomer V2.0 prediction for src kinase-associated phosphoprotein 2 (Q3UND0) · a predicted model of the same protein · chain B against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3UND0
- Elsewhere: RCSB PDB 2OTX · PDBe 2OTX · UniProt Q3UND0
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