Research workbench
Crystal structure of fv polyglutamine complex
Analyse Crystal structure of fv polyglutamine complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OTU
- Type
- protein
- Length
- 976 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fv light chain variable domain; Fv heavy chain variable domain; Peptide antigen
- UniProt
- A2NN81
- Pockets
- 8 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Fv light chain variable domain | protein | 115 | 5% helix, 49% strand | — |
| B, D, F, H | Fv heavy chain variable domain | protein | 118 | 8% helix, 54% strand | A2NN81 |
| P, Q, R, S | Peptide antigen | protein | 11 | 0% helix, 9% strand | — |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1045 | 0.83 | 0.84 | 94 | empty |
| 2 | 1154 | 0.78 | 0.80 | 96 | empty |
| 3 | 380 | 0.63 | 0.78 | 58 | empty |
| 4 | 139 | 0.43 | 0.75 | 27 | empty |
| 5 | 137 | 0.41 | 0.74 | 20 | empty |
Interfaces
27 interfaces between chains.
- C–D · 952 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 948 Ų buried · 7 hydrogen bonds · protein-protein
- G–H · 926 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 909 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 531 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2OTU · Crystal structure of Fv polyglutamine complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A2NN81
- Elsewhere: RCSB PDB 2OTU · PDBe 2OTU · UniProt A2NN81
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.