Research workbench
Structure of NUP58/45 suggests flexible nuclear pore diameter by intermolecular sliding
Analyse Structure of NUP58/45 suggests flexible nuclear pore diameter by intermolecular… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OSZ
- Type
- protein
- Length
- 344 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin P58/P45
- UniProt
- P70581
- Pockets
- 4 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 92% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Nucleoporin P58/P45 | protein | 86 | 92% helix, 0% strand | P70581 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.34 | 0.76 | 15 | empty |
| 2 | 62 | 0.32 | 0.76 | 11 | empty |
| 3 | 52 | 0.30 | 0.76 | 11 | empty |
| 4 | 57 | 0.30 | 0.75 | 15 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1360 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1310 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 706 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 92 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 77 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2OSZ · Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding · the same entry in another collection · chain A against A, TM-score 1.00
- P70581 · AlphaFold monomer V2.0 prediction for nucleoporin P58/P45 (P70581) · a predicted model of the same protein · chain A against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70581
- Elsewhere: RCSB PDB 2OSZ · PDBe 2OSZ · UniProt P70581
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