Research workbench
The X-ray crystal structure of the 65KDA isoform of glutamic acid decarboxylase (GAD65)
Analyse The X-ray crystal structure of the 65KDA isoform of glutamic acid decarboxylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OKK
- Type
- protein
- Length
- 483 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate decarboxylase 2
- EC
- 4.1.1.15
- UniProt
- Q05329
- Ligands
- ABU
- Pockets
- 5 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate decarboxylase 2 (EC 4.1.1.15) | protein | 483 | 48% helix, 14% strand | Q05329 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.48 | 0.77 | 29 | empty |
| 2 | 110 | 0.45 | 0.78 | 24 | empty |
| 3 | 74 | 0.32 | 0.74 | 18 | empty |
| 4 | 86 | 0.32 | 0.73 | 22 | ABU |
| 5 | 50 | 0.24 | 0.72 | 15 | empty |
Modifications
Observed in the structure: 1 modified (cofactor).
Compared structures
- 2OKK · The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65) · the same entry in another collection · chain A against A, TM-score 1.00
- Q05329 · AlphaFold monomer V2.0 prediction for glutamate decarboxylase 2 (Q05329) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05329
- Elsewhere: RCSB PDB 2OKK · PDBe 2OKK · UniProt Q05329
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