Research workbench

Anti-DNA antibody ED10

Analyse Anti-DNA antibody ED10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2OJZ
Type: protein
Length: 868 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab ED10 light chain; Fab ED10 heavy chain
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L, M	Fab ED10 light chain	protein	218	6% helix, 50% strand	—
H, I	Fab ED10 heavy chain	protein	216	8% helix, 53% strand	—

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1106	0.73	0.77	97	empty
2	187	0.52	0.78	31	empty
3	156	0.51	0.79	26	empty
4	296	0.50	0.73	51	empty
5	228	0.47	0.74	38	empty

Interfaces

4 interfaces between chains.

M–I · 1820 Å² buried · 16 hydrogen bonds · protein-protein
L–H · 1820 Å² buried · 16 hydrogen bonds · protein-protein
L–I · 360 Å² buried · 9 hydrogen bonds · protein-protein
H–M · 348 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

2OJZ · Anti-DNA antibody ED10 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2OJZ · PDBe 2OJZ

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.