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Crystal structure of human transthyretin in complex with resveratrol

Analyse Crystal structure of human transthyretin in complex with resveratrol in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1DVS
Type: protein
Length: 229 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transthyretin
UniProt: P02766
Ligands: STL
Pockets: 2 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transthyretin	protein	115	5% helix, 53% strand	P02766
B	Transthyretin	protein	114	5% helix, 52% strand	P02766

Ligands and binding sites

STL · Resveratrol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.31	0.75	14	empty
2	63	0.29	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 926 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1DVS · Crystal structure of human transthyretin in complex with resveratrol · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02766
Elsewhere: RCSB PDB 1DVS · PDBe 1DVS · UniProt P02766

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