Research workbench
Structural and mutational analysis of tRNA-intron splicing endonuclease from thermoplasma acidophilum DSM1728
Analyse Structural and mutational analysis of tRNA-intron splicing endonuclease from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OHC
- Type
- protein
- Length
- 577 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA-splicing endonuclease
- EC
- 3.1.27.9
- UniProt
- Q9HIY5
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA-splicing endonuclease (EC 3.1.27.9) | protein | 289 | 26% helix, 33% strand | Q9HIY5 |
| B | TRNA-splicing endonuclease (EC 3.1.27.9) | protein | 288 | 27% helix, 31% strand | Q9HIY5 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 632 | 0.67 | 0.77 | 83 | empty |
| 2 | 116 | 0.38 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2038 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2OHC · structural and mutational analysis of tRNA-intron splicing endonuclease from Thermoplasma… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HIY5 · AlphaFold monomer V2.0 prediction for tRNA-splicing endonuclease (Q9HIY5) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HIY5
- Elsewhere: RCSB PDB 2OHC · PDBe 2OHC · UniProt Q9HIY5
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