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Crystal structure and binding epitopes of urokinase-type plasminogen activator (C122A/N145Q/S195A) in complex with inhibitors

Analyse Crystal structure and binding epitopes of urokinase-type plasminogen activator… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2O8W
Type: protein
Length: 245 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urokinase plasminogen activator
EC: 3.4.21.73
UniProt: Q5PY49
Ligands: PL0, SO4
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Urokinase plasminogen activator (EC 3.4.21.73)	protein	245	10% helix, 39% strand	Q5PY49

Ligands and binding sites

PL0 · 1-phenylguanidine · ligand · chains A
SO4 · Sulfate ion · ion · chains A
PG4 · Tetraethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	167	0.44	0.75	32	SO4, PL0

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

2O8W · Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5PY49
Elsewhere: RCSB PDB 2O8W · PDBe 2O8W · UniProt Q5PY49

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